Morphogen gradients in development: from form to function
نویسندگان
چکیده
منابع مشابه
Development: Morphogen gradients and mesodermal patterning
Activin has long-range effects in Xenopus development, inducing the mesodermally expressed brachyury gene up to 10 cell diameters from a localised source. Recent experiments show that activin diffuses through tissues to establish a morphogen gradient, and that the long-range effects are a direct result of activin signalling.
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Shh activity and at different distances from the source. The proper functioning of tissues and organs requires These observations provide unequivocal evidence that that each cell differentiate appropriately for its position. Shh acts directly on distant cells and therefore that Shh In many cases, the positional information that instructs forms a morphogen gradient in the developing neural cells...
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Successful biological development via spatial and temporal regulations of cell differentiation relies on the action of multiple signaling molecules that are known as morphogens. It is now well established that biological signaling molecules create nonuniform concentration profiles, called morphogen gradients, that activate different genes, leading to patterning in the developing organisms. The ...
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ژورنال
عنوان ژورنال: Wiley Interdisciplinary Reviews: Developmental Biology
سال: 2011
ISSN: 1759-7684
DOI: 10.1002/wdev.2